Adrenosterone , also known as Reichstein's substance G , as well as 11-ketoandrostenedione ( 11-KA4 ), 11-oxoandrostenedione ( 11-OXO ), and androst-4-ene-3,11,17-trione , is a steroid hormone with a weak androgenic effect, and an intermediate / prohormone of 11-ketotestosterone .  It was first isolated in 1936 from the adrenal cortex by Tadeus Reichstein at the Pharmaceutical Institute in the University of Basel . Originally, adrenosterone was called Reichstein's substance G. Adrenosterone occurs in trace amounts in humans as well as most mammals and in larger amounts in fish, where it is a precursor to the primary androgen, 11-ketotestosterone . 
Man made (synthetic) corticosteriods are used to treat a large number of conditions and symptoms. Corticosteriods are used as a replacement therapy when the body is not naturally producing enough of its own of natural corticosteriods. They are also used to treat conditions where there is inflammation, autoimmune conditions or allergy symptoms. Corticosteriod can be taken orally as a systemic treatment to treat the body as a whole or it can be applied to the affected area for a local effect as creams, inhalations, nasal sprays, eye drops, ear drops or injections. Examples of conditions they treat are allergies, asthma, COPD, dermatitis, ulcerative colitis, Crohn’s disease, multiple sclerosis, nephrotic syndrome, adrenal insufficiency, inflammation, Addison’s disease, rheumatic conditions such as arthritis, fibromyalgia and lupus.