Anabolic pathways of metabolism are pathways that

Anabolic processes tend toward "building up" organs and tissues . These processes produce growth and differentiation of cells and increase in body size, a process that involves synthesis of complex molecules . Examples of anabolic processes include the growth and mineralization of bone and increases in muscle mass. Endocrinologists have traditionally classified hormones as anabolic or catabolic, depending on which part of metabolism they stimulate. The classic anabolic hormones are the anabolic steroids , which stimulate protein synthesis, muscle growth, and insulin . [3] The balance between anabolism and catabolism is also regulated by circadian rhythms , with processes such as glucose metabolism fluctuating to match an animal's normal periods of activity throughout the day. [4]

Several studies concluded that diets low in fat (under 15% of total calories) significantly decreased testosterone levels while diets higher in fat (above 30% of total calories) increased serum testosterone levels. Rather than continuing with this discussion I will provide a link to an article which covers the subject quite nicely. To simplify everything that I have said, it seems that one should not lower fat below 15% of daily calories unless they would like to face extreme testosterone deficiencies. Likewise, one should not increase fat to say 40% in order to increase testosterone. Although fat increases testosterone to a degree, it is important to remember that testosterone is only a small piece of the larger puzzle. There are many other hormones and factors involved in building muscle other than just testosterone. By increasing fat to extremely high levels, there will be less “space” for carbohydrates and protein, both of which are very important for aforementioned reasons.

This article is invaluable – scientific but still accessible. I listen to your podcast, as well as that of Robb Wolf and Ben Greenfield, and you all recently ‘encouraged’ me to take the leap into a ketogenic diet (I’ve been primal/paleo for about 6 months). I’ve been fully in ketosis now for about 10 days and while I truly wouldn’t have believed anyone who told me my cravings would disappear, they have and it’s liberating beyond measure (not that it’s relevant but my ration is about 1400 kcal, 8% carb, 15% protein, 77% fat). My energy is stable and consistently high, my sleep is excellent, my gym sessions have been surprisingly good (although short fast burst training seems to be suffering a bit but I’m hopeful I’ll adapt). I haven’t lost a lot of fat but that wasn’t really my goal (I’m a fit 45 yr old female, 125 lbs, bmi of 20) although I’m as vain as the next person who claims they aren’t, lol! Anyway, I’ve been curious about this benefit from ketosis and couldn’t find a succinct and scientific explanation until now. You’re kind of an arrogant jerk sometimes (Mom’s Thanksgiving stuffing comes to mind…) but humility is overrated and we need confident, unwavering voices to help override the prevailing nonsense – don’t you go changing! And thanks for the great info. 🙂


Figure 2. The structure of ATP. ATP is derived from the nucleotide adenosine monophosphate (AMP) or adenylic acid, to which two additional phosphate groups are attached through pyrophosphate bonds (~P). These two bonds are energy rich in the sense that their hydrolysis yields a great deal more energy than a corresponding covalent bond. ATP acts as a coenzyme in energetic coupling reactions wherein one or both of the terminal phosphate groups is removed from the ATP molecule with the bond energy being used to transfer part of the ATP  to another molecule to activate its role in metabolism. For example, Glucose + ATP -----> Glucose-P + ADP  or  Amino Acid + ATP -----> AMP-Amino Acid + PPi.

Anabolic pathways of metabolism are pathways that

anabolic pathways of metabolism are pathways that


Figure 2. The structure of ATP. ATP is derived from the nucleotide adenosine monophosphate (AMP) or adenylic acid, to which two additional phosphate groups are attached through pyrophosphate bonds (~P). These two bonds are energy rich in the sense that their hydrolysis yields a great deal more energy than a corresponding covalent bond. ATP acts as a coenzyme in energetic coupling reactions wherein one or both of the terminal phosphate groups is removed from the ATP molecule with the bond energy being used to transfer part of the ATP  to another molecule to activate its role in metabolism. For example, Glucose + ATP -----> Glucose-P + ADP  or  Amino Acid + ATP -----> AMP-Amino Acid + PPi.

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