Dose and administration: Apply hydrocortisone cream to the affected area as a thin film 2 to 4 times daily depending on the severity of the condition. It is not likely other drugs you take orally or inject will have an effect on topically applied hydrocortisone. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, hydrocortisone should be used only when prescribed. Infants born to mothers who have been using this medication for an extended period of time may have hormone problems. Tell your doctor if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn. This medication passes into breast milk. However, this drug is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
Samples for serum cortisol are taken at t=0 (typically 8am) prior to the patient’s first hydrocortisone dose, then at one, two, five and nine hours after this dose. For patients taking hydrocortisone three times a day, the second dose should be given after the five hour sample and the third after the nine hour sample. Patients taking hydrocortisone twice daily should take their second dose at seven hours with an additional sample taken at that time. Clearly mark the patient’s details, date and time on each bottle.