Non liver toxic anabolic steroids

Abnormal LFTs do not necessarily indicate any underlying abnormality of function. Traditionally, 'normal' values are defined as being within ± 2 standard deviations of the mean (of a normally distributed range), meaning that just over 95% of a healthy population will fall within the 'normal range', but % of a normal population will be normal outliers lying above it, and a further % will be normal outliers lying below it. However, as liver disease is frequently asymptomatic, this argument should not be used as an excuse for inadequate investigation. Abnormal LFTs are often inadequately investigated - which may miss an early opportunity of identifying and treating chronic liver disease [ 4 ] .

Treatment: If a pancreatic or liver tumor is identified and able to be surgically excised, the skin lesions may normalize for an extended period of time, but because these tumors metastasize (spread to other areas of the body) quickly, surgery is not curative. In cases of end stage liver disease, surgery is not possible, and the goal of therapy is to increase quality of life and decrease uncomfortable skin lesions with supportive care and addressing the nutritional abnormalities. Supportive care includes supplementing protein and necessary minerals and enzymes through the diet and oral supplements or by weekly intravenous amino acid infusions that are performed in the hospital on an outpatient basis until improvement in the skin is noted. Unfortunately, despite the supportive care, the disease will progress.

A very typical case of severe cholestasis due to anabolic steroid use.  Because the steroids were being used without medical supervision, the dose and actual duration of use of each preparation was unclear, but cholestasis usually arises within 4 to 12 weeks of starting a C-17 alkylated androgenic steroid.  The jaundice can be severe and prolonged and accompanied by severe pruritus and marked weight loss.  The serum enzymes are typically minimally elevated except for a short period immediately after stopping therapy.  The pattern of enzyme elevations can be hepatocellular, cholestatic or mixed.  Liver biopsy shows a “bland” cholestasis with minimal inflammation and hepatocellular necrosis.  Ma Huang has also been implicated in cases of drug induced liver injury, but is associated with an acute hepatocellular pattern of injury.

References:
1. J Clin Gastroenterol. 2002 Oct;35(4):350-2. Androgenic/Anabolic steroid-induced toxic hepatitis.
Stimac D, Milić S, Dintinjana RD, Kovac D, Ristić S.
2. Clin Ther. 2001 Jun;23(6):789-801; discussion 771. Review of oxymetholone: a 17alpha-alkylated anabolic-androgenic AM1, Fultz O, Monberg MJ, Vootkur A, Pharmd.
3. HIV Hotline. 1998 Dec;8(5-6):10-1. Does the choice of alpha-AAS really make a difference? Mutzebaugh C.
4. Minerva Med. 1971 Jun 27;62(51):2605-11. [Hepatotoxicity of anabolic steroids]. Rozman C, Urbano A, Galera H.
5. J Gastroenterol 2000;35(7):557-62, Multiple hepatic adenomas caused by long-term administration of androgenic steroids for aplastic anemia in association with familial adenomatous polyposis. Nakao A, Sakagami K, Nakata Y, Komazawa K, Amimoto T, Nakashima K, Isozaki H, Takakura N, Tanaka N.
6. Medical Hypotheses 93 (2016) 150–153. Anabolic androgenic steroid-induced hepatotoxicity. Peter Bond, William Llewellyn, Peter Van Mol
7. Med Sci Sports Exerc. 1999 Feb;31(2):243-50, Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids. Molano F, Saborido A, Delgado J, Moran M, Megias A.
8. Lancet 1979 Nov 24;2(8152):1120-3, Hepatic angiosarcoma associated with androgenic-anabolic steroids. Falk H, Thomas LB, Popper H, Ishak KG.
9. J Pharmacol Toxicol Methods 1995 Aug;33(4):187-95, Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures. Welder AA, Robertson JW, Melchert RB.
10. Arch Toxicol 1999 Nov;73(8-9):465-72, Evaluation of acute and chronic hepatotoxic effects exerted by anabolic-androgenic steroid stanozolol in adult male rats. Boada LD, Zumbado M, Torres S, Lopez A, Diaz-Chico BN, Cabrera JJ, Luzardo OP.
11. Clin J Sport Med 1999 Jan;9(1):34-9, Anabolic steroid-induced hepatotoxicity: is it overstated? Dickerman RD, Pertusi RM, Zachariah NY, Dufour DR, McConathy WJ.
12. Int J Sports Med 1996 Aug;17(6):429-33, Body composition, cardiovascular risk factors and liver function in long-term androgenic-anabolic steroids using bodybuilders three months after drug withdrawal. Hartgens F, Kuipers H, Wijnen JA, Keizer HA.

My Chihuahua had a high ALT so after researching I put her on Stella and Chewys freeze dried raw chicken diet. I gave her carrots for treats with occasional piece of cheese. Once in a while I’ll give her fresh raw children and or fish but she’s a chihuahua and VERY picky so she rarely eats fresh raw. Anyway I took her back a month later for lab work and her levels are almost back to normal!! I take her back again in three months but its looking good so far. The best part is that I leave the food out and she free feeds when she’s hungry. Freeze dried doesn’t go bad easily.

Non liver toxic anabolic steroids

non liver toxic anabolic steroids

References:
1. J Clin Gastroenterol. 2002 Oct;35(4):350-2. Androgenic/Anabolic steroid-induced toxic hepatitis.
Stimac D, Milić S, Dintinjana RD, Kovac D, Ristić S.
2. Clin Ther. 2001 Jun;23(6):789-801; discussion 771. Review of oxymetholone: a 17alpha-alkylated anabolic-androgenic AM1, Fultz O, Monberg MJ, Vootkur A, Pharmd.
3. HIV Hotline. 1998 Dec;8(5-6):10-1. Does the choice of alpha-AAS really make a difference? Mutzebaugh C.
4. Minerva Med. 1971 Jun 27;62(51):2605-11. [Hepatotoxicity of anabolic steroids]. Rozman C, Urbano A, Galera H.
5. J Gastroenterol 2000;35(7):557-62, Multiple hepatic adenomas caused by long-term administration of androgenic steroids for aplastic anemia in association with familial adenomatous polyposis. Nakao A, Sakagami K, Nakata Y, Komazawa K, Amimoto T, Nakashima K, Isozaki H, Takakura N, Tanaka N.
6. Medical Hypotheses 93 (2016) 150–153. Anabolic androgenic steroid-induced hepatotoxicity. Peter Bond, William Llewellyn, Peter Van Mol
7. Med Sci Sports Exerc. 1999 Feb;31(2):243-50, Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids. Molano F, Saborido A, Delgado J, Moran M, Megias A.
8. Lancet 1979 Nov 24;2(8152):1120-3, Hepatic angiosarcoma associated with androgenic-anabolic steroids. Falk H, Thomas LB, Popper H, Ishak KG.
9. J Pharmacol Toxicol Methods 1995 Aug;33(4):187-95, Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures. Welder AA, Robertson JW, Melchert RB.
10. Arch Toxicol 1999 Nov;73(8-9):465-72, Evaluation of acute and chronic hepatotoxic effects exerted by anabolic-androgenic steroid stanozolol in adult male rats. Boada LD, Zumbado M, Torres S, Lopez A, Diaz-Chico BN, Cabrera JJ, Luzardo OP.
11. Clin J Sport Med 1999 Jan;9(1):34-9, Anabolic steroid-induced hepatotoxicity: is it overstated? Dickerman RD, Pertusi RM, Zachariah NY, Dufour DR, McConathy WJ.
12. Int J Sports Med 1996 Aug;17(6):429-33, Body composition, cardiovascular risk factors and liver function in long-term androgenic-anabolic steroids using bodybuilders three months after drug withdrawal. Hartgens F, Kuipers H, Wijnen JA, Keizer HA.

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