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Changes in clinical condition were evaluated first by the subjective scoring of the investigator, then by masked assessment of videotapes of the neurological examination. At 5 mg/kg for 28 days, 28 of 47 horses (60%) improved at least one grade by Day 118. Seventy-five percent (75%) of those improved, that had also been videotaped, were corroborated successes by videotape assessment. At 10 mg/kg, 32 of 55 animals (58%) improved at least one grade by Day 118 and 56% of those improved, that had also been videotaped, were corroborated successes using videotape assessment. With respect to the clinical investigators’ scores there was no statistical difference between 5 mg/kg and 10 mg/kg treatment group results (p = ).

The follow-up singles were also successful. The second single, "No", features Argentinian singer-songwriter Gustavo Cerati and reached numbers two and eleven, respectively, on the Billboard Latin Pop Songs and Latin Songs charts. [17] [25] The video was filmed in a black-and-white effect, [26] and was directed by Jaume de Laiguana . [27] After the release of " Don't Bother " as the lead single from Oral Fixation, Vol. 2 in late 2005, [28] " Día de Enero " was the third single from Fijación Oral, Vol. 1 . [29] It peaked at numbers seven and twenty-nine on the Billboard Latin Pop Songs and Latin Songs charts, respectively. [17] Like "No", its accompanying video was directed by de Laiguana. The clip refers to Shakira's then-boyfriend Antonio de la Rúa as she writes the letters "S y A" in a heart drawn in the sand. [30]

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