Physical side effects of anabolic steroid abuse

Concordant with the functional roles of the brain structures that exhibit increased gray matter volumes, regular exercise over a period of several months has been shown to persistently improve numerous executive functions and several forms of memory. [5] [7] [9] [60] [61] [62] In particular, consistent aerobic exercise has been shown to improve attentional control , [note 3] information processing speed , cognitive flexibility (., task switching ), inhibitory control , [note 4] working memory updating and capacity, [note 5] declarative memory , [note 6] and spatial memory . [5] [6] [7] [9] [10] [60] [61] In healthy young and middle-aged adults, the effect sizes of improvements in cognitive function are largest for indices of executive functions and small to moderate for aspects of memory and information processing speed. [1] [10] It may be that in older adults, individuals benefit cognitively by taking part in both aerobic and resistance type exercise of at least moderate intensity. [64] Individuals who have a sedentary lifestyle tend to have impaired executive functions relative to other more physically active non-exercisers. [9] [60] A reciprocal relationship between exercise and executive functions has also been noted: improvements in executive control processes, such as attentional control and inhibitory control, increase an individual's tendency to exercise. [9]

I used creatine 8 or so years ago, had great gains, ( it was the exact same product then & dont tell me its gotten better becasue its effervescent or some .) But I also had a frequent & uncomfortable need to urinate that was NOT just from consuming extra liquid, but from my kidneys being put on overload & doing damage to them with this stuff. I drank plenty of water, took a little less than the recommended dose & was having the urination problem for years after the use of creatine… I also was very short tempered with my family & young kids at the time I took it as it altered my mood.
I also have a friend who underwent a kidney transplant, that if he didnt get, he would have died . the reason for his kidney failure was creatine & he would tell you to stay far away from it as it almost costed him his life. This stuff is absolutely no good-

13. Frank, ., “Induced Abortion Operations and Their Early Sequelae”, Journal of the Royal College of General Practitioners (April 1985),35(73):175-180; Grimes DA, Cates W Jr.  Abortion:  Methods and complications.  In:  Hafez ESE, ed.  Human reproduction:  Conception and contraception  (2nd ed).  Hagerstown, Maryland:  Harper and Row, 1980:796‑813.; . Freedman, “Comparison of complication rates in first trimester abortions performed by physician assistants and physicians,” Am. J. Public Health, 76(5):550- 554 (1986).

And, exacerbating these two age-related erosive events, some catabolites of tryptophan can lead to the formation of mutagenic nitrosamines or the activation of an immunosuppressive receptor (which is usually triggered by toxicants such as xenobiotics), promoting carcinogenesis (Mezrich, et al., 2010; Chung & Gadupudi, 2011).

The consumption of a supplement of tryptophan will likely nurture or augment these disastrous age-associated disease states, by raising injurious tryptophan derivatives (particularly in the presence of a vitamin B6 deficiency, an insufficiency of stomach acid, a magnesium deficit, and a vitamin B3 deficiency).

Furthermore, tryptophan side effects in regards to greater mortality were shown in animal experiments (., Catrina, et al., 2001) using melatonin, whereas the study authors cautioned:

“[...] melatonin had a deleterious effect on the survival rate raising the question whether it is correct to assume that the hormone shows lack of adverse reactions.” [emphasis added]

In regard to serotonin's involvement in the promotion of higher mortality, one of its anti-longevity effects is conceivably the reabsorption of phosphate (a pro-inflammatory chemical) by the kidneys since klotho, an anti-aging protein, facilitates the excretion of phosphate from the kidneys (Peat, Nov. 2012).

Since tryptophan, serotonin, and melatonin meddle with basic energy production in cells, and since metabolic efficiency and functionality decreases proportionally with aging (Fannin, et al., 1999; O'Toole, et al., 2010) due to various factors, it seems coherent in biological terms that these substances are less prevalent, thus less “essential” or needed, in older people, as a further decrease of an already suboptimal general metabolic working order will aggravate physiological function systematically, increase the risk for disease (as exemplified and foreshadowed with tryptophan side effects), promote the aging process, and explains the increased mortality related to the administration of these substances.

Several tryptophan side effects, such as tryptophan's carcinogenic activities, the deterioration of metabolic energy function, and the promotion of hypertension, can rather readily account for a greater death rate.

Physical side effects of anabolic steroid abuse

physical side effects of anabolic steroid abuse

And, exacerbating these two age-related erosive events, some catabolites of tryptophan can lead to the formation of mutagenic nitrosamines or the activation of an immunosuppressive receptor (which is usually triggered by toxicants such as xenobiotics), promoting carcinogenesis (Mezrich, et al., 2010; Chung & Gadupudi, 2011).

The consumption of a supplement of tryptophan will likely nurture or augment these disastrous age-associated disease states, by raising injurious tryptophan derivatives (particularly in the presence of a vitamin B6 deficiency, an insufficiency of stomach acid, a magnesium deficit, and a vitamin B3 deficiency).

Furthermore, tryptophan side effects in regards to greater mortality were shown in animal experiments (., Catrina, et al., 2001) using melatonin, whereas the study authors cautioned:

“[...] melatonin had a deleterious effect on the survival rate raising the question whether it is correct to assume that the hormone shows lack of adverse reactions.” [emphasis added]

In regard to serotonin's involvement in the promotion of higher mortality, one of its anti-longevity effects is conceivably the reabsorption of phosphate (a pro-inflammatory chemical) by the kidneys since klotho, an anti-aging protein, facilitates the excretion of phosphate from the kidneys (Peat, Nov. 2012).

Since tryptophan, serotonin, and melatonin meddle with basic energy production in cells, and since metabolic efficiency and functionality decreases proportionally with aging (Fannin, et al., 1999; O'Toole, et al., 2010) due to various factors, it seems coherent in biological terms that these substances are less prevalent, thus less “essential” or needed, in older people, as a further decrease of an already suboptimal general metabolic working order will aggravate physiological function systematically, increase the risk for disease (as exemplified and foreshadowed with tryptophan side effects), promote the aging process, and explains the increased mortality related to the administration of these substances.

Several tryptophan side effects, such as tryptophan's carcinogenic activities, the deterioration of metabolic energy function, and the promotion of hypertension, can rather readily account for a greater death rate.

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