Sindrome de cushing inducido por esteroides

Cushing's syndrome is a condition that occurs when the body's tissues are constantly exposed to too much of the hormone cortisol. The syndrome is named after a brain surgeon, Harvey Cushing, who identified the condition in 1932. Cortisol is produced by the body's two adrenal (pronounced uh-DREEN-l) glands either in response to stress or when the cortisol levels in the blood are lower than they should be. Cortisol is a type of glucocorticoid (pronounced GLOO-koh-KAWR-tuh-koid) or steroid (pronounced STEER-oid or STER-oid) hormone.

In those patients not suited for or unwilling to undergo surgery, several drugs have been found to inhibit cortisol synthesis (. ketoconazole , metyrapone ) but they are of limited efficacy. [ citation needed ] Mifepristone is a powerful glucocorticoid type II receptor antagonist and, since it does not interfere with normal cortisol homeostatis type I receptor transmission, may be especially useful for treating the cognitive effects of Cushing's syndrome. [39] However, the medication faces considerable controversy due to its use as an abortifacient . In February 2012, the FDA approved mifepristone to control high blood sugar levels ( hyperglycemia ) in adult patients who are not candidates for surgery, or who did not respond to prior surgery, with the warning that mifepristone should never be used by pregnant women. [40]

Una densidad <10 UH del tumor en la TC sin contraste puede diagnosticar una lesión suprarrenal benigna, con una sensibilidad del 96-100% y una especificidad del 50-100%. En los adenomas con escaso líquido se presentan dificultades diagnósticas, ya que presentan alores de atenuación >10 UH y se estima que constituyen hasta el 30% de todos los adenomas. Se señala que la mayor parte de los incidentalomas suprarrenales son descubiertos por las TC realizadas con el uso de medios de contraste por vía intravenosa, una técnica clasificada como subóptima. En efecto, en tales casos. se debe hacer una TC sin contraste.

Sindrome de cushing inducido por esteroides

sindrome de cushing inducido por esteroides

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