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Other notable derivatives then result from further modification of this template, with saturation of the 7,8-double bond of etorphine resulting in the even more potent dihydroetorphine (up to 12,000× potency of morphine) and acetylation of the 3-hydroxy group of etorphine resulting in acetorphine (8700× morphine)—although while the isopentyl homologue of etorphine is nearly three times more potent, its 7,8-dihydro and 3-acetyl derivatives are less potent than the corresponding derivatives of etorphine at 11000× and 1300× morphine respectively. Replacing the N-methyl group with cyclopropylmethyl results in opioid antagonists such as diprenorphine (M5050, which is used as an antidote to reverse the effects of etorphine, M99), and partial agonists such as buprenorphine , which is widely used in the treatment of opioid addiction.

If you’ve ever pondered the metaphysical question that has kept the best thinkers up at night – “Is my life a video game?”, Diesel and Street Fighter V attempt to provide a much-needed answer. To commemorate the 30th anniversary of the Street Fighter iconic video game, the game that was birthed in 1987 teams up with Italian clothing company Diesel to make your feet feel like they are indeed walking on the ones and zeros that make up a battle-heavy binary coded world. See it here: http:///…/diesel-and-street-fighter-v-cap…/

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