Arlan L Rosenbloom, MD Adjunct Distinguished Service Professor Emeritus of Pediatrics, University of Florida College of Medicine; Fellow of the American Academy of Pediatrics; Fellow of the American College of Epidemiology
Arlan L Rosenbloom, MD is a member of the following medical societies: American Academy of Pediatrics , American College of Epidemiology , American Pediatric Society , Endocrine Society , Pediatric Endocrine Society , Society for Pediatric Research , Florida Chapter of The American Academy of Pediatrics, Florida Pediatric Society , International Society for Pediatric and Adolescent Diabetes
Disclosure: Nothing to disclose.
Biosynthesis of steroid hormones requires a battery of oxidative enzymes located in both mitochondria and endoplasmic reticulum. The rate-limiting step in this process is the transport of free cholesterol from the cytoplasm into mitochondria. Within mitochondria, cholesterol is converted to pregnenolone by an enzyme in the inner membrane called CYP11A1. Pregnenolone itself is not a hormone, but is the immediate precursor for the synthesis of all of the steroid hormones. The following table delineates the enzymes required to synthesize the major classes of steroid hormones.
Hi Brad, really bummed you haven’t been getting great sleep for such a long time! I would lose my mind if that was me. While balancing hormones and keeping up your nutrition is very important for adrenal support, there are some herbs out their that might help you finally get that rest you’ve been seeking. Two that we sell currently are Ziziphus and Albizia. The Ziziphus is great for the type of insomnia that wakes you from sleep. Albizia is better at relaxing the body so you can fall asleep in the first place. We recently upgrading our sleep bundle which had ziziphus and ashwagandha (helps relax the body and control cortisol levels) to include albizia. We will be pushing it next week but it is already available for purchase.