In the Oxford Journal of Gerontology Series A: Biological Sciences and Medical Sciences, the popular nonsteroidal SARM LGD 4033 (Ligandrol) has been recently studied for it’s effectiveness and safety in healthy young men. Results were favorable indicated by hormone and lipid levels returning to normal without the use of a post cycle therapy. No dangers were detected throughout the study. although there was noticeable suppression in testosterone and HDL cholesterol, it was not significant enough to cause adverse reactions. Because LGD 4033 is considered one of the strongest and most potent nonsteroidal SARMs available, it is not likely that less potent SARMs will produce any harmful effects (Bhasin, 2010).
Given the nature of many of the androgenic and estrogenic side effects from Trenbolone, it is often difficult to minimize the risk of negative effects while still preserving the efficacy of the drug. There are certainly methods that bodybuilders use to minimize the likelihood of harmful reactions, and the most important would be only taking anabolic-androgenic steroids under the supervision of a doctor who is well-versed in steroid use.
I think that if most bodybuilders objectively consider the long-term risks versus the short-term gains, it really won’t seem worth it in the end.